I'm dating this at 1963 based on the presence of the Mandarin Hotel (opened in 1963), and the absence of the second-generation Z-shaped Blake Pier, which appeared around 1964. Corrections welcome!
In the lower-right of the photo is Admiralty district, undergoing major changes as the old Royal Naval dockyards area is gradually redeveloped. We've written about those changes before.
Lots of the buildings we've talked about appear in this photo. Let me know if there are any more you think deserve to be added to the list below.
And any suggestions where the photograph was taken from?